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 Research at OSU Dermatology
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OSU Dermatology is actively involved in both basic science and clinical research.  Dr. Anjali Mishra, who leads the basic science team, has been the receipt of multiple grants and has developed the only mouse cutaneous lymphoma model which is integral in the study of CTCL.  Our clinical research team, led by Dr. Jessica Kaffenberger and Dr. Ben Kaffenberger, is involved in many clinical trials and has been recognized as a top recruiting site on numerous clinical trials.  Major areas of investigation are listed below.


BASIC SCIENCE RESEARCH

Dr. Mishra's research is focused on identifying the cellular reprogramming steps interleukin-15 (IL-15) induces to initiate malignant change in T lymphocytes. Dr. Mishra’s laboratory has shown stage-related IL-15 mRNA and protein over-expression in lesional skin and circulating tumor cells of CTCL patients. Using IL-15 transgenic (tg) mice, Dr. Mishra's lab has characterized an animal model of spontaneous epidermotropic T-cell lymphoma that clinically and pathologically mimics human CTCL. The research efforts of her laboratory are focused on understanding the mechanisms of lymphomagenesis and designing therapeutic strategies for CTCL, by characterizing and targeting deregulated oncogenic pathways in IL-15 tg mice and in CTCL patients.

Over expression of IL-15 in skin lesion from a CTCL patient.

 

 

                                                                                   

In mice, overexpression of IL-15 induces a spontaneous CTCL that mimics the human neoplasm.


CLINICAL RESEARCH

 The Clinical Research Department at OSU Dermatology is active in multiple clinical trials investigating potential new therapies for the treatment of skin conditions including psoriasis, hidradenitis suppurativa, pyoderma gangrenosum, lupus erythematous and cutaneous T-cell lymphoma.  There are also several registries examining the long term safety and efficacy of psoriasis treatments. In order to better understand the pathogenesis of certain skin diseases, we also participate in the OSU Biorepository, which consists of a biospecimen bank to store samples from patients with a variety of skin diseases.

Our experienced research staff includes:

Dr. Jessica Kaffenberger, M.D.: Principal Investigator

Dr. Benjamin Kaffenberger, M.D.: Principal Investigator

Lisa Hafer, MPH, CCRP: Clinical Research Coordinator

Aleitha Gates, LPN: Clinical Research Coordinator

Dermatology Research Fellows - Justin Hastings, Jaime Alexander: Sub-Investigators

   

In mice, overexpression of IL-15 induces a spontaneous CTCL that mimics the human neoplasm.

    

 

 

 

Overexpression of IL-15 in skinlesionfrom a CTCL patient.


In mice, overexpression of IL-15 induces a spontaneous CTCL that mimics the human neoplasm.

 

    


 

 

 

 

Overexpression of IL-15 in skin                               lesion from a CTCL patient.


In mice, overexpression of IL-15 induces a spontaneous CTCL that mimics the human neoplasm.

 

    


 

 

 

 

Overexpression of IL-15 in skin                               lesion from a CTCL patient.


In mice, overexpression of IL-15 induces a spontaneous CTCL that mimics the human neoplasm.

 

    


 





Contact Us:

 

Jessica Kaffenberger, MD

Principal Investigator

Jessica.Kaffenberger@osumc.edu

 

Benjamin Kaffenberger, MD

Principal Investigator

Benjamin.Kaffenberger@osumc.edu

 

Lisa Hafer, MPH, CCRP

Clinical Research Coordinator

614.366.2025

Lisa.Hafer@osumc.edu



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